MYOCARDIAL RESPONSES TO CHELATION

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Myocardial responses to chelation.

The phenomena of displacement and immobilization of calcium ions by chelation is being studied in an increasing number of clinical states. Chelation therapy in hypercalcmmia (Holland et al., 1953; Spencer et al., 1956), calcium deposition in coronary arteries (Meltzer et al., 1960) and peripheral vessels (Clarke et al., 1960) and in skin (Muller et al., 1959), and in the treatment of digitalis ...

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Effect of iron chelation on myocardial infarct size and oxidative stress in ST-elevation-myocardial infarction.

BACKGROUND Experimental studies suggest that deferoxamine (DFO) limits the generation of reactive oxygen species by chelating redox-active iron and thereby may reduce ischemia-reperfusion injury and myocardial infarct (MI) size. We investigated whether DFO administered before reperfusion by primary percutaneous coronary intervention (PPCI) would ameliorate oxidative stress and MI size. METHOD...

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Lead toxicosis of captive vultures: case description and responses to chelation therapy

BACKGROUND Lead, a serious threat for raptors, can hamper the success of their conservation. This study reports on experience with accidental lead intoxication and responses to chelation therapy in captive Cinereous (Aegypius monachus) and Egyptian (Neophron percnopterus) Vultures. RESULTS Soil contamination by lead-based paint sanded off the steel aviary resulted in poisoning of eight Cinere...

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The effect of an EDTA-based chelation regimen on patients with diabetes mellitus and prior myocardial infarction in the Trial to Assess Chelation Therapy (TACT).

BACKGROUND The Trial to Assess Chelation Therapy (TACT) showed clinical benefit of an EDTA-based infusion regimen in patients aged ≥50 years with prior myocardial infarction. Diabetes mellitus before enrollment was a prespecified subgroup. METHODS AND RESULTS Patients received 40 infusions of EDTA chelation or placebo. A total of 633 (37%) patients had diabetes mellitus (322 EDTA and 311 plac...

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Prior Myocardial Infarction in the Trial to Assess Chelation Therapy ( TACT ) The Effect of an EDTA - based Chelation Regimen on Patients With Diabetes

Rosenberg, Richard L. Nahin, Pamela Ouyang, Theodore Rozema, Allan Magaziner, Richard Esteban Escolar, Gervasio A. Lamas, Daniel B. Mark, Robin Boineau, Christine Goertz, Yves Prior Myocardial Infarction in the Trial to Assess Chelation Therapy (TACT) The Effect of an EDTA-based Chelation Regimen on Patients With Diabetes Mellitus and Print ISSN: 1941-7705. Online ISSN: 1941-7713 Copyright © 20...

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ژورنال

عنوان ژورنال: Heart

سال: 1961

ISSN: 1355-6037

DOI: 10.1136/hrt.23.6.690